MaGIC has three overarching areas of research: clinical research (utilizing the clinical trials data), basic and translational research, and the development and running of clinical trials.

Underpinning each of these efforts is the MaGIC Data Commons, housed within the Pediatric Cancer Data Commons (PCDC Data Portal), which includes accumulated clinical data from over 3,500 patients, the associated biospecimens, and the publicly available genomic data attached to these patients and biospecimens.